The Fox Inheritance is the sequel to The Adoration of Jenna Fox, though I don’t think you’d have to read the first to get the second. In any case, I’ll try not to spoil the first one for you since it’s one of my favorites.
It’s 260 years after Locke and Kara were in what should have been a fatal car accident, and one year after their consciousnesses (which had been stored in black boxes in the interim) have been restored to bodies. The BioPerfect gel that makes up most of them means they’ll probably live another 400 to 600 years in these new bodies, but what good does that do you if you’ve been mentally damaged by spending those 260 years stuck in those boxes with no one to communicate with except each other. Kara and Locke are having some trouble readjusting to life with bodies, to say the least.
When they discover that the doctor who has restored them really only wants them around as floor models for his illegal business, they decide to make their escape, enlisting a legless taxi-driving bot Dot Jefferson to help them navigate both physically and culturally in a world that is very different from the one they left. They discover that Jenna (who was also in the accident and the focus of The Adoration) is alive, and has had a new body since right after the accident, the must see her.
Not only is this book a rousing adventure, with a cross country trip where Locke and Kara are split up and pursued by the doctor, but it also raises important issues about biotechnology, what it means to be human, and what it means to be a friend. Locke is stuck between a lot of things, including his two best friends, and it’s fascinating to watch him work through all the different kinds of challenges he faces.